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Respirology

Pulmonary Alveolar Proteinosis in Greece–Türkiye–Cyprus: Answers in a Real‐Life Comparison

Study Takeaway
Reinforces the role of Whole Lung Lavage (WLL) as the gold standard treatment for symptomatic PAP.
The European respiratory journal

Safety and efficacy of inhaled itraconazole in adults with asthma and allergic bronchopulmonary aspergillosis (PUR1900-ABPA): a randomized, double-blind, parallel group, placebo-controlled, multicenter, phase 2 trial.

Study Takeaway
For interventional pulmonologists, the 40 mg dose of inhaled PUR1900 showed a favorable safety profile and was associated with improvements in FEV1 (placebo-adjusted LSM +0.28 L; 95% CI 0.02, 0.53), supporting further phase 3 evaluation.
BMC pulmonary medicine

Trends in mortality involving coexisting lung cancer and sepsis in the United States: a CDC WONDER analysis, 1999-2024.

Study Takeaway
Mortality involving coexisting lung cancer and sepsis increased over the study period, with the overall age-adjusted mortality rate rising from 1.6 to 2.0 per 100,000 population, highlighting significant demographic and geographic disparities that demand targeted public health strategies and improved access to care.
BMC pulmonary medicine

Association between corticosteroid exposure during chest-tube placement and pleurodesis failure in malignant pleural effusion: a retrospective analysis.

Study Takeaway
Multi-day corticosteroid use during chest-tube placement, along with poor performance status, was associated with pleurodesis failure in patients with malignant pleural effusion. Clinicians should interpret these hypothesis-generating findings with caution due to potential confounding factors.
Thorax

Metered cryospray in patients with chronic bronchitis: a mechanistic randomised controlled study.

Study Takeaway
While metered cryospray did not significantly reduce goblet cell density at 6 months (P = 0.49), it improved symptom burden on the St George's Respiratory Questionnaire (-9.6 points, P = 0.022) and reduced radiological air trapping, suggesting it is a safe and promising treatment to explore further in interventional pulmonology practice.
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