The complementary roles of endobronchial ultrasound-guided needle aspiration, mini-forceps, and cryobiopsy in the investigation of mediastinal lesions.
Study Takeaway
While overall diagnostic yield was similar across modalities, TBCB provided significantly higher-quality tissue for molecular profiling assays (P = 0.002) and less crush artifact compared to TBFB (P < 0.0001). Clinicians should consider supplementing EBUS-TBNA with TBFB or TBCB when suspecting inflammatory or lymphoproliferative conditions, or when high-quality tissue is needed for molecular assays.