Ultrasonic elastography-guided pleural biopsy followed by as-needed semi-rigid thoracoscopic pleural biopsy versus immediate semi-rigid thoracoscopic pleural biopsy for the diagnosis of pleural effusion (UPDATE-3): a protocol of randomised controlled trial.
Study Takeaway
This trial will determine if starting with ultrasound elastography-guided biopsy is non-inferior to semi-rigid thoracoscopy using a non-inferiority margin of - 5% for diagnostic yield, potentially shifting practice toward a less invasive step-up approach and reducing the need for thoracoscopy.